Stand Up To Cancer’s mission is to raise funds to accelerate the pace of groundbreaking translational research that can get new therapies to patients quickly and save lives now.
Since 2008, SU2C’s innovative research model has brought more effective treatments to patients at an unparalleled pace. We bring together today’s top scientists to work toward treatments faster. Follow along with the #ThisIsSU2C hashtag.
Traditionally, scientists worked individually on different pieces of the cancer puzzle. Stand Up To Cancer enables scientists to work together on Dream Teams, with members in different disciplines and from multiple institutions, pooling their expertise to accelerate the process of finding better ways to treat cancer.
Collaboration doesn't stop there. Not only do our Dream Teams collaborate within teams, they collaborate across them as well–because what we learn in one cancer type often has great application to other cancer types. Each year, SU2C holds a Scientific Summit that allows our researchers and advocates to share and discuss the progress of their research. Get a recap of the 2015 annual summit here.
We invest in cutting edge cancer research ideas that may be considered high risk, but have a strong potential to impact patient care. In addition to Dream Teams, we continue to fund Innovative Research Grants. These grants are awarded to the “young guns” of cancer research with fresh ideas that may not receive funding from traditional sources and could one day lead to life changing results. Get a closer look at the cutting edge research supported by our Innovative Research Grants thus far.
We have integrated levels and types of collaboration into our program that are truly distinctive in cancer research. Not only do we bring scientists and physicians together to form Dream Teams, we bring experts from other fields who offer novel approaches to cutting-edge cancer research. This idea of bringing other disciplines to cancer research, including mathematics, information technology, and quantum physics is called convergence.
"By merging cancer research with the physical, computational and engineering sciences, 'convergence' offers the potential for revolutionary advances and more rapid innovation in the understanding and control of cancer."
Arnold Levine, Ph.D., Professor at the Institute for Advanced Study and Vice Chair of SU2C's Scientific Advisory Committee
Celebrities who volunteer their time as SU2C ambassadors play a critical role in SU2C's far-reaching impact. Employees and artists of every professional level working at studios, networks, guilds, talent agencies and other entertainment companies donate their time, talent and resources to support SU2C's work.
With cancer research changing at a rapid pace, SU2C is staying ahead of the game with the latest and greatest technologies fueling our progress. Get to know these exciting new treatments and technologies and how our Dream Teams are using them.
SU2C researchers in the Netherlands developed a radical new technology to test anti-cancer drugs quickly: tumor organoids. These actual, living cells from patients’ tumors — grown in three dimensions — mimic the structure and biology of cancer tumors. Kept in the lab, these “tumors in a dish” allow for drugs to be tested much more quickly and will speed up the search for effective therapies.Meet the Organoid Dream Team
Immunotherapy — a new approach that uses the body’s own immune system to help fight cancer — is an exciting new frontier of cancer treatment. SU2C is among the organizations at the forefront of this promising research field and is investing millions of dollars toward immunotherapy.Meet Our Immunology Dream Team
Among the Dream Teams also using immunotherapy are:
The pediatric cancer Dream Team is testing T-cell therapy for leukemia and other childhood cancers to expand its use and impact.
This pancreatic cancer Dream Team is exploring new approaches that could enhance anticancer immune response in pancreatic cancer.
The HPV Translational Team has identified molecular “flags” that can be targeted to attack HPV-associated cancers.
Precision Medicine (targeted treatment) is an approach to diagnosing and treating a disease based on a patient’s specific genetic and biological makeup. If doctors have the right information, they can design medical treatments based on an individual patient’s DNA sequence.Meet the Precision Medicine Translational Team
Among the Dream Teams also using precision medicine are:
The Melanoma Dream Team has launched a clinical trial to match the specific genetics of melanoma in individual patients to the most effective drugs. If successful, the research will speed treatment for people with this terminal form of skin cancer.
The Prostate Cancer Dream Team discovered specific genetic alterations (mutations) in prostate cancer that can potentially be treated with existing drugs.
The Pancreatic Cancer Dream Team discovered a genetic predictor of survival in some people and specific genetic alterations (mutations) in pancreatic cancer that existing drugs might work on, opening up new possibilities for treatment.
On average, an experimental cancer drug can take 12 - 15 years to be developed and get final approval from the FDA. SU2C’s unique approach has accelerated development of effective therapies and supported research that led to FDA approval bringing real health benefits to cancer patients. Here are some results from SU2C-supported research.
SU2C has contributed to TWO recent drug approvals in the last 7 years.
After members of the Breast Cancer Dream Team demonstrated that the drug palbociclib (Ibrance) was effective, it received accelerated approval from the FDA.
Members of one of the Pancreatic Cancer Dream Teams showed the effectiveness of a two-drug combination (Abraxane plus gemcitabine), leading to FDA approval. The Dream Team is now testing new three-drug combinations.
Epigenetics Dream Team
After promising results in early clinical trials, the VARI-SU2C Epigenetics Dream Team is currently conducting larger clinical trials on a new drug in development that shows promise for patients with Acute Myeloid Leukemia.
Women's Cancers Dream Team
The Phosphatidylinositol 3 Kinase (PI3K) Dream Team showed that a two-drug combination holds promise for ovarian and breast cancer treatment.
“Scientists supported by SU2C have made important findings in advanced prostate cancer.”Read More
“Pancreatic Cancer Dream Team shows hope for Vitamin D to help treat pancreatic cancer.”Read More
“Possible therapeutic targets found in comprehensive genome study in lung cancer; research supported by SU2C.”Read More
This is SU2C’s ultimate goal. 1600 people die every day from cancer in the US and SU2C’s mission is to change that. We have impacted many patients’ lives because of SU2C supported scientific research. Here are a few of their stories and how SU2C has impacted their lives.
“The overall purpose is to move effective new therapies out of the lab and into the clinic at a much faster pace. It’s the collective wisdom of researchers from many different institutions that’s making things move much more rapidly."
Dr. Phillip Sharp
"It has greatly increased my awareness of all things to do with prostate cancer, let alone contributing to my continued survival through the PARP Inhibitor trial."
"I'm very happy to be involved with Stand Up To Cancer and feel it's important to be part of their research — by giving blood or tissue — to help study this disease and maybe help other people with better treatments."